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Thermoregulation: why you shiver during a fever

Your guide: Miss AimanThinks the human body is the best-designed machine in the syllabus.

The problem

You have a 39 °C fever, yet you pull on a blanket and shiver like it is winter. That feels backwards. Surely a hot body should want to cool down, not warm up further?

It is not backwards. Chemicals called pyrogens, made by pathogens and blood cells during infection, push the hypothalamus's set point up from 37 °C to something higher, say 39 °C. Your body is still near 37 °C, so it is now cold relative to that new target, and it shivers to catch up.

Fever is not the thermostat breaking. It is the same control system defending a deliberately higher set point.

Pyrogens, produced by pathogens and blood cells during infection, displace the hypothalamus's set point above the normal 37 °C. Fever is the body working to reach that new, higher set point, which helps trigger the body's protective mechanisms against the pathogens.

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